Diseases can turn an expedition into a rescue mission or give a settlement an urgent need for help. Contaminated supplies, an infected animal, or a supernatural affliction can put adventurers and the people around them at risk.
Use each disease's description for its symptoms, spread, effects, and treatment. Do not assume that a healing spell also cures disease; check the spell or ability's stated effects. Finding a remedy, delivering supplies, or tracing an outbreak can become an adventure of its own.
When creating a disease, establish how exposure occurs, when symptoms appear, which creatures it can affect, and what recovery requires. Give players clues they can investigate and meaningful ways to respond. Any limits involving ancestry or creature type should be stated in the disease's description.